GLUT5, Fructose, and Skeletal Muscle

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  • #3797

    Spuey
    Keymaster

    I've always been under the impression that fructose can only be stored in the liver, however this article:http://www.ncbi.nlm.nih.gov/pubmed/9781312Clearly states that there are fructose transporters (GLUT5) in muscle tissue, while exercising definitely doesn't activate them, is there a possibility that fructose can be stored in muscle?

    #79811

    maxwkw
    Member

    From what I understand (which is little) fructose goes to refill lived glycogen first, but can then be used elsewhere in the body.

    #79812

    Brandon D Christ
    Participant

    There are GLUT5 in the muscle tissues and in other tissues, but the ability of the muscles (and fat tissue) to clear fructose from the blood is minor because of low concentration of GLUT5 mRNA and GLUT5 transport proteins.  The reason excess fructose can make you fat, is unlike glucose, which can be metabolized anywhere in the body, fructose is mainly metabolized in the liver.  It is important to note that insulin can increase GLUT5 functional activity in muscles, but it is still rather minor compared to the intenstines (ironically I don't think GLUT5 exists in the liver) which absorbs it transports it to the liver for processing.  You know the rest, if the liver can store more glycogen it will convert the fructose to glycogen, if not it will turn it into triglycerides and stored as fat.The brain, kidneys, and oddly the testicles also have GLUT5.Good article to read about it:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652499/

    #79813

    Spuey
    Guest

    Thanks for clearing that up, and that article is gonna take a while to digest haha. Now if there was a magical diet or exercise that could increase Glut5 expression in muscle….life would be so good.

    #79814

    guitarjon
    Participant

    There are GLUT5 in the muscle tissues and in other tissues, but the ability of the muscles (and fat tissue) to clear fructose from the blood is minor because of low concentration of GLUT5 mRNA and GLUT5 transport proteins.  The reason excess fructose can make you fat, is unlike glucose, which can be metabolized anywhere in the body, fructose is mainly metabolized in the liver.  It is important to note that insulin can increase GLUT5 functional activity in muscles, but it is still rather minor compared to the intenstines (ironically I don't think GLUT5 exists in the liver) which absorbs it transports it to the liver for processing.  You know the rest, if the liver can store more glycogen it will convert the fructose to glycogen, if not it will turn it into triglycerides and stored as fat.The brain, kidneys, and oddly the testicles also have GLUT5.Good article to read about it:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652499/

    So I just want to get this straight, I'll use tonight as an example; I'm doing a backload immediately after training my legs and it will last 3 hours max.  One of the items on the menu is an apple/blackberry pie.  Is it best to wait until maybe the last hour of the backload (around the time I understand fat to be more appropriate), or would it be best to have it early on so that there is less chance of my glycogen stores being full?

    #79815

    Brandon D Christ
    Participant

    There are GLUT5 in the muscle tissues and in other tissues, but the ability of the muscles (and fat tissue) to clear fructose from the blood is minor because of low concentration of GLUT5 mRNA and GLUT5 transport proteins.  The reason excess fructose can make you fat, is unlike glucose, which can be metabolized anywhere in the body, fructose is mainly metabolized in the liver.  It is important to note that insulin can increase GLUT5 functional activity in muscles, but it is still rather minor compared to the intenstines (ironically I don't think GLUT5 exists in the liver) which absorbs it transports it to the liver for processing.  You know the rest, if the liver can store more glycogen it will convert the fructose to glycogen, if not it will turn it into triglycerides and stored as fat.The brain, kidneys, and oddly the testicles also have GLUT5.Good article to read about it:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652499/

    So I just want to get this straight, I'll use tonight as an example; I'm doing a backload immediately after training my legs and it will last 3 hours max.  One of the items on the menu is an apple/blackberry pie.  Is it best to wait until maybe the last hour of the backload (around the time I understand fat to be more appropriate), or would it be best to have it early on so that there is less chance of my glycogen stores being full?

    Yes consume it at the end of the backload.  That is what Kiefer would suggest.  I don't have a clue how the whole glucose/fructose liver glycogen storage works.  I would speculate that as long as you control the total fructose ingested, it doesn't matter.  The number we suggest on the forums is a max of 60 g per day.  Remember table sugar is half fructose. 

    #79816

    guitarjon
    Participant

    There are GLUT5 in the muscle tissues and in other tissues, but the ability of the muscles (and fat tissue) to clear fructose from the blood is minor because of low concentration of GLUT5 mRNA and GLUT5 transport proteins.  The reason excess fructose can make you fat, is unlike glucose, which can be metabolized anywhere in the body, fructose is mainly metabolized in the liver.  It is important to note that insulin can increase GLUT5 functional activity in muscles, but it is still rather minor compared to the intenstines (ironically I don't think GLUT5 exists in the liver) which absorbs it transports it to the liver for processing.  You know the rest, if the liver can store more glycogen it will convert the fructose to glycogen, if not it will turn it into triglycerides and stored as fat.The brain, kidneys, and oddly the testicles also have GLUT5.Good article to read about it:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652499/

    So I just want to get this straight, I'll use tonight as an example; I'm doing a backload immediately after training my legs and it will last 3 hours max.  One of the items on the menu is an apple/blackberry pie.  Is it best to wait until maybe the last hour of the backload (around the time I understand fat to be more appropriate), or would it be best to have it early on so that there is less chance of my glycogen stores being full?

    Yes consume it at the end of the backload.  That is what Kiefer would suggest.  I don't have a clue how the whole glucose/fructose liver glycogen storage works.  I would speculate that as long as you control the total fructose ingested, it doesn't matter.  The number we suggest on the forums is a max of 60 g per day.  Remember table sugar is half fructose.

    Ok thanks, I've actually gone with sticky rice for the majority of my carbs for these past 2 backloads, and I feel pretty good.  I've also had a few bowls of rice krispies, some cherry conserve (no HFCS), as well as a small amount of ice cream to finish off.  I don't know for sure how much fructose is included in all of that stuff but I'm definitely working on dialling it back.

    #79817

    Brandon D Christ
    Participant

    There are GLUT5 in the muscle tissues and in other tissues, but the ability of the muscles (and fat tissue) to clear fructose from the blood is minor because of low concentration of GLUT5 mRNA and GLUT5 transport proteins.  The reason excess fructose can make you fat, is unlike glucose, which can be metabolized anywhere in the body, fructose is mainly metabolized in the liver.  It is important to note that insulin can increase GLUT5 functional activity in muscles, but it is still rather minor compared to the intenstines (ironically I don't think GLUT5 exists in the liver) which absorbs it transports it to the liver for processing.  You know the rest, if the liver can store more glycogen it will convert the fructose to glycogen, if not it will turn it into triglycerides and stored as fat.The brain, kidneys, and oddly the testicles also have GLUT5.Good article to read about it:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652499/

    So I just want to get this straight, I'll use tonight as an example; I'm doing a backload immediately after training my legs and it will last 3 hours max.  One of the items on the menu is an apple/blackberry pie.  Is it best to wait until maybe the last hour of the backload (around the time I understand fat to be more appropriate), or would it be best to have it early on so that there is less chance of my glycogen stores being full?

    Yes consume it at the end of the backload.  That is what Kiefer would suggest.  I don't have a clue how the whole glucose/fructose liver glycogen storage works.  I would speculate that as long as you control the total fructose ingested, it doesn't matter.  The number we suggest on the forums is a max of 60 g per day.  Remember table sugar is half fructose.

    Ok thanks, I've actually gone with sticky rice for the majority of my carbs for these past 2 backloads, and I feel pretty good.  I've also had a few bowls of rice krispies, some cherry conserve (no HFCS), as well as a small amount of ice cream to finish off.  I don't know for sure how much fructose is included in all of that stuff but I'm definitely working on dialling it back.

    Fructose is something that needs to be controlled.  I would say a big problem with people when they start this diet is they woof down so many sweets and they end up with a massive amount of fructose, which turns into fat.

    #79818

    guitarjon
    Participant

    There are GLUT5 in the muscle tissues and in other tissues, but the ability of the muscles (and fat tissue) to clear fructose from the blood is minor because of low concentration of GLUT5 mRNA and GLUT5 transport proteins.  The reason excess fructose can make you fat, is unlike glucose, which can be metabolized anywhere in the body, fructose is mainly metabolized in the liver.  It is important to note that insulin can increase GLUT5 functional activity in muscles, but it is still rather minor compared to the intenstines (ironically I don't think GLUT5 exists in the liver) which absorbs it transports it to the liver for processing.  You know the rest, if the liver can store more glycogen it will convert the fructose to glycogen, if not it will turn it into triglycerides and stored as fat.The brain, kidneys, and oddly the testicles also have GLUT5.Good article to read about it:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652499/

    So I just want to get this straight, I'll use tonight as an example; I'm doing a backload immediately after training my legs and it will last 3 hours max.  One of the items on the menu is an apple/blackberry pie.  Is it best to wait until maybe the last hour of the backload (around the time I understand fat to be more appropriate), or would it be best to have it early on so that there is less chance of my glycogen stores being full?

    Yes consume it at the end of the backload.  That is what Kiefer would suggest.  I don't have a clue how the whole glucose/fructose liver glycogen storage works.  I would speculate that as long as you control the total fructose ingested, it doesn't matter.  The number we suggest on the forums is a max of 60 g per day.  Remember table sugar is half fructose.

    Ok thanks, I've actually gone with sticky rice for the majority of my carbs for these past 2 backloads, and I feel pretty good.  I've also had a few bowls of rice krispies, some cherry conserve (no HFCS), as well as a small amount of ice cream to finish off.  I don't know for sure how much fructose is included in all of that stuff but I'm definitely working on dialling it back.

    Fructose is something that needs to be controlled.  I would say a big problem with people when they start this diet is they woof down so many sweets and they end up with a massive amount of fructose, which turns into fat.

    I can totally relate to that.  It's taken me the past month and a bunch excessive backloads to start actually understanding how to make it work.  I think it's really difficult to hold back at first, especially when I've made a habit of being so strict the past couple of years.  In the process of all this backloading, I am looking a lot more closely at what I eat and how to alter it to make it suitable for the purpose.  It really isn't just as simple as eating a bunch of sugary garbage-not if you want to have a positive experience with it.  At this point I think I have to accept the fact that I might not necessarily stay super lean at first, and it'll take a bit of time, trial and probably a lot of error to really work it out and actually build some real mass for once.  I know I'll learn a lot from it anyway. 

    #79819

    guitarjon
    Participant

    Also, sorry about the rant, I must still be a bit jacked up from my backload.

    #79820

    Zach516
    Member

    There are GLUT5 in the muscle tissues and in other tissues, but the ability of the muscles (and fat tissue) to clear fructose from the blood is minor because of low concentration of GLUT5 mRNA and GLUT5 transport proteins.  The reason excess fructose can make you fat, is unlike glucose, which can be metabolized anywhere in the body, fructose is mainly metabolized in the liver.  It is important to note that insulin can increase GLUT5 functional activity in muscles, but it is still rather minor compared to the intenstines (ironically I don't think GLUT5 exists in the liver) which absorbs it transports it to the liver for processing.  You know the rest, if the liver can store more glycogen it will convert the fructose to glycogen, if not it will turn it into triglycerides and stored as fat.The brain, kidneys, and oddly the testicles also have GLUT5.Good article to read about it:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652499/

    So I just want to get this straight, I'll use tonight as an example; I'm doing a backload immediately after training my legs and it will last 3 hours max.  One of the items on the menu is an apple/blackberry pie.  Is it best to wait until maybe the last hour of the backload (around the time I understand fat to be more appropriate), or would it be best to have it early on so that there is less chance of my glycogen stores being full?

    Yes consume it at the end of the backload.  That is what Kiefer would suggest.  I don't have a clue how the whole glucose/fructose liver glycogen storage works.  I would speculate that as long as you control the total fructose ingested, it doesn't matter.  The number we suggest on the forums is a max of 60 g per day.  Remember table sugar is half fructose.

    Ok thanks, I've actually gone with sticky rice for the majority of my carbs for these past 2 backloads, and I feel pretty good.  I've also had a few bowls of rice krispies, some cherry conserve (no HFCS), as well as a small amount of ice cream to finish off.  I don't know for sure how much fructose is included in all of that stuff but I'm definitely working on dialling it back.

    Fructose is something that needs to be controlled.  I would say a big problem with people when they start this diet is they woof down so many sweets and they end up with a massive amount of fructose, which turns into fat.

    I agree with this, and it seems to happen on any refeed based diet, not just CBL. What I've noticed in myself (n=1) Is that I've never pushed it to where it is fat gain, but it does cause me to retain unusually high amounts of water. So even that is a risk when consuming a large amount of fructose.

    #79821

    Fairy
    Guest

    There are GLUT5 in the muscle tissues and in other tissues, but the ability of the muscles (and fat tissue) to clear fructose from the blood is minor because of low concentration of GLUT5 mRNA and GLUT5 transport proteins.  The reason excess fructose can make you fat, is unlike glucose, which can be metabolized anywhere in the body, fructose is mainly metabolized in the liver.  It is important to note that insulin can increase GLUT5 functional activity in muscles, but it is still rather minor compared to the intenstines (ironically I don't think GLUT5 exists in the liver) which absorbs it transports it to the liver for processing.  You know the rest, if the liver can store more glycogen it will convert the fructose to glycogen, if not it will turn it into triglycerides and stored as fat.The brain, kidneys, and oddly the testicles also have GLUT5.Good article to read about it:  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652499/

    So I just want to get this straight, I'll use tonight as an example; I'm doing a backload immediately after training my legs and it will last 3 hours max.  One of the items on the menu is an apple/blackberry pie.  Is it best to wait until maybe the last hour of the backload (around the time I understand fat to be more appropriate), or would it be best to have it early on so that there is less chance of my glycogen stores being full?

    Yes consume it at the end of the backload.  That is what Kiefer would suggest.  I don't have a clue how the whole glucose/fructose liver glycogen storage works.  I would speculate that as long as you control the total fructose ingested, it doesn't matter.  The number we suggest on the forums is a max of 60 g per day.  Remember table sugar is half fructose.

    Ok thanks, I've actually gone with sticky rice for the majority of my carbs for these past 2 backloads, and I feel pretty good.  I've also had a few bowls of rice krispies, some cherry conserve (no HFCS), as well as a small amount of ice cream to finish off.  I don't know for sure how much fructose is included in all of that stuff but I'm definitely working on dialling it back.

    Fructose is something that needs to be controlled.  I would say a big problem with people when they start this diet is they woof down so many sweets and they end up with a massive amount of fructose, which turns into fat.

    I can totally relate to that.  It's taken me the past month and a bunch excessive backloads to start actually understanding how to make it work.  I think it's really difficult to hold back at first, especially when I've made a habit of being so strict the past couple of years.  In the process of all this backloading, I am looking a lot more closely at what I eat and how to alter it to make it suitable for the purpose.  It really isn't just as simple as eating a bunch of sugary garbage-not if you want to have a positive experience with it.  At this point I think I have to accept the fact that I might not necessarily stay super lean at first, and it'll take a bit of time, trial and probably a lot of error to really work it out and actually build some real mass for once.  I know I'll learn a lot from it anyway.

    +1 I had to learn this the hard way too 🙂 Glad I know it now. Rice is going to be my backloading staple

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GLUT5, Fructose, and Skeletal Muscle

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