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Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats. Sengsirisuwan V, et al.http://jap.physiology.org/content/91/1/145.long-oral glucose tolerance tests with zucker rats show increased GLUT4, reduced glucose and insulin responses in exercise and exercise + alpha lipoic acidThoughts?
Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats. Sengsirisuwan V, et al.http://jap.physiology.org/content/91/1/145.long-oral glucose tolerance tests with zucker rats show increased GLUT4, reduced glucose and insulin responses in exercise and exercise + alpha lipoic acidThoughts?
I always thought ALA spiked insulin, and was especially useful post-workout w/ carbs, creatine and proteins.I have heard that while it spikes insulin, it doesn't cause fat storage, and that Germans had done tests w/ ALA on diabetics.Read something about this in a 2009 Muscle & Fitness, I believe.Cory
So according to you the optimal times to take ALA would only be after training, so pretty much treat it like leucine? Thanks again.
My understanding of ALA is that it functions somewhat like insulin, clearing blood glucose and shuttling componds (such as creatine) without the need for carbs thus sparing the actual insulin response. I further understand that ALA, in particular the R-isomer (R-ALA), was attempted to be patented by pharmaceutical companies because of its efficacy in reducing blood glucose in diabetic patients, but the attempt was denied because of the nature of the compound being inherently 'naturally occuring.' It has been proven to help reduce nerve pain in cases of diabetic neuropathy.Finally, patients taking drugs like metformin as well as those on insulin have to adjust their dosages if taking R-ALA due to its effects on blood glucose levels.
My understanding of ALA is that it functions somewhat like insulin, clearing blood glucose and shuttling componds (such as creatine) without the need for carbs thus sparing the actual insulin response. I further understand that ALA, in particular the R-isomer (R-ALA), was attempted to be patented by pharmaceutical companies because of its efficacy in reducing blood glucose in diabetic patients, but the attempt was denied because of the nature of the compound being inherently 'naturally occuring.' It has been proven to help reduce nerve pain in cases of diabetic neuropathy.Finally, patients taking drugs like metformin as well as those on insulin have to adjust their dosages if taking R-ALA due to its effects on blood glucose levels.
Yes, so let's have some help in figuring out whether or not it's muscle specific or all tissues. The thing that is confusing I think is that it helps reduce bodyfat by assisting or increasing insulin sensitivity...so the mechanism, what does the insulin sensitivity do that makes it easier to lose bodyfat? Thoughts.
The way I think about it is, it increases insulin sensitivity/decreases insulin resistance by giving the receptors a break by doing insulin's job so there isn't so much of it flooding your system (for our carb-crazy society) all the time wearing those receptors out.So I'm thinking that less insulin needed to do the job of clearing the glucose, etc., the faster levels return to normal leading to less suppression of GH by an unfavorable high-insulin environment (GH and insulin levels are inversely related). So the more GH is around, the more FAs are released in this low-insulin environment.
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