Isoleucine better than Leucine for Glut-4 expression in muscles

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  • #141856

    Gl;itch.e
    Member

    Why not just get a normal BCAAs supplement?  It has Isoleucine in it.  Just add enough to get your 5g of leucine in your shakes.  You can find BCAA mixes for roughly the same price as leucine(if not cheaper).

    This!I just take BCAAs post-workout.  Most mixes are 2:1:1 in favor of Leucine, mine is 8:1:1.Cory

    You didnt read the article did you! (;

    #141857

    Jake
    Member

    For people that carb back load on off days the nights before they lift I believe that isoleucine would be very beneficial since those people do not have the glut4 activation induced from exercise; thus, this amino acid could possibly replace the effect of exercise on these nights. 

    #141858

    Gl;itch.e
    Member

    For people that carb back load on off days the nights before they lift I believe that isoleucine would be very beneficial since those people do not have the glut4 activation induced from exercise; thus, this amino acid could possibly replace the effect of exercise on these nights.

    I dont know if I'd go that far! you are always going to be getting Isoleucine when you are eating protein foods. And in that case I doubt the isolated amino would be of any use beyond whats already in the food youd be eating. The benefit could possibly come from being able to take this isolated amino when NOT taking in other proteins (during the fasted periods or periods of low protein intake)

    #141859

    storm47
    Member

    If I bought some  Isoleucine, what dosage would someone recommend?

    #141860

    Jake
    Member

    For people that carb back load on off days the nights before they lift I believe that isoleucine would be very beneficial since those people do not have the glut4 activation induced from exercise; thus, this amino acid could possibly replace the effect of exercise on these nights.

    I dont know if I'd go that far! you are always going to be getting Isoleucine when you are eating protein foods. And in that case I doubt the isolated amino would be of any use beyond whats already in the food youd be eating. The benefit could possibly come from being able to take this isolated amino when NOT taking in other proteins (during the fasted periods or periods of low protein intake)

    Thats exactly what the article is talking about though - taking isoleucine with carbohydrates and thus why the article ends up recommending the amino acid with meals to direct the glucose to your muscles.

    #141861

    Gl;itch.e
    Member

    For people that carb back load on off days the nights before they lift I believe that isoleucine would be very beneficial since those people do not have the glut4 activation induced from exercise; thus, this amino acid could possibly replace the effect of exercise on these nights.

    I dont know if I'd go that far! you are always going to be getting Isoleucine when you are eating protein foods. And in that case I doubt the isolated amino would be of any use beyond whats already in the food youd be eating. The benefit could possibly come from being able to take this isolated amino when NOT taking in other proteins (during the fasted periods or periods of low protein intake)

    Thats exactly what the article is talking about though - taking isoleucine with carbohydrates and thus why the article ends up recommending the amino acid with meals to direct the glucose to your muscles.

    Indeed. But in that regard its basically useless to us as we are already eating protein with our carb meals. Where it gets interesting is Isoleucines potential to shuttle glucose to muscles without the presence of carbs. If this works itd allow more rapid emptying of the glycogen in the liver during ULC periods. I could be way off and Id love to hear someone like Kiefer share his thoughts on the matter.

    #141862

    Gl;itch.e
    Member

    If I bought some  Isoleucine, what dosage would someone recommend?

    You would be the last person Id recommend trying this experiment Storm. Youd be even more likely to go hypoglycemic than the people I think could benefit from trying this (i.e. those with more bodyfat to lose) I think a dosage around 2-3 grams would be what I'd try.

    #141863

    tzanghi
    Participant

    For people that carb back load on off days the nights before they lift I believe that isoleucine would be very beneficial since those people do not have the glut4 activation induced from exercise; thus, this amino acid could possibly replace the effect of exercise on these nights.

    A good point.  I would suggest this as well.

    #141864

    tzanghi
    Participant

    If it has any use or relevance to us DHers we'd want to use Isoleucine on its own during the ULC period. Whey or BCAAs would contain leucine which does effect insulin levels. This way we'd be getting the effect we want without the calories/insulin spike to sabotage it. Its all conjecture obviously because I have no idea if itd actually work! Its only a thought at this stage.

    Keep in mind that isoleucine does raise insulin levels(though I'm not sure to what degree).

    #141865

    Gl;itch.e
    Member

    If it has any use or relevance to us DHers we'd want to use Isoleucine on its own during the ULC period. Whey or BCAAs would contain leucine which does effect insulin levels. This way we'd be getting the effect we want without the calories/insulin spike to sabotage it. Its all conjecture obviously because I have no idea if itd actually work! Its only a thought at this stage.

    Keep in mind that isoleucine does raise insulin levels(though I'm not sure to what degree).

    LEUCINE does. Isoleucine on its own does not

    #141866

    storm47
    Member

    Gl;itch.e,I could be extremely wrong on the use of Isoleucine for me!  I thought if I ingested it post workout with protein and carbs, the Isoleucine would rapidly empty my glycogen in my liver and the glucose from my liver and ingested carbs would fill my GLUT-4 cells in my muscles to the max.  Then I could ingest more carbs to refill my liver.  Or ingest Isoleucine on my off days during back loading to fill my GLUT-4 cells in my muscles to the max.Why is it used during ULC to rapidly empty glycogen in the liver?I read the article several times but I am still confused.Gl;itch.e or anyone else, am I very wrong about the use for me?

    #141867

    Richard Schmitt
    Moderator

    It's been posted on Facebook twice and hope to hear back from Kiefer on it as well

    #141868

    tzanghi
    Participant

    If it has any use or relevance to us DHers we'd want to use Isoleucine on its own during the ULC period. Whey or BCAAs would contain leucine which does effect insulin levels. This way we'd be getting the effect we want without the calories/insulin spike to sabotage it. Its all conjecture obviously because I have no idea if itd actually work! Its only a thought at this stage.

    Keep in mind that isoleucine does raise insulin levels(though I'm not sure to what degree).

    LEUCINE does. Isoleucine on its own does not

    http://www.marksdailyapple.com/dairy-insulin/#axzz2K4yGTVJW

    It comes down to the amino acid composition of dairy proteins, specifically the amino acids leucine, valine, lysine, and isoleucine. These are the truly insulinogenic proteins...

    #141869

    Why not just get a normal BCAAs supplement?  It has Isoleucine in it.  Just add enough to get your 5g of leucine in your shakes.  You can find BCAA mixes for roughly the same price as leucine(if not cheaper).

    This!I just take BCAAs post-workout.  Most mixes are 2:1:1 in favor of Leucine, mine is 8:1:1.Cory

    You didnt read the article did you! (;

    Not yet.  LOL!  ;DCory

    #141870

    tzanghi
    Participant

    Perhaps this is just above my scientific reasoning level, but I don't quite get the conclusion of the article from the data.  1st off, the rats were fasting for 15 straight hours prior to feeding, which could have confounding effects on its own.  Secondly, the isoleucine solution didn't even result in the most glycogen stored in muscle.  I didn't really see an adequate answer in the “where did the glucose go” paragraph either.What am I missing?

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Isoleucine better than Leucine for Glut-4 expression in muscles

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