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Just found these very interesting studies on a blog hosted by Dr. Michael R. Eades. These findings may explain why low carb/ high fat diets work so good even if one is not in a caloric deficit.When ATP levels fall in the cell, signals go out to the parts of the metabolic system that are responsible for harvesting the energy from stored sugar and fat to create the high energy electrons required to make more ATP.AMPK is one of the primary signaling proteins that monitors the ATP levels in the cells and signals for more energy when levels drop. When AMPK is activated indicating our cellular energy tanks are depleted, all kinds of good things happen.Study: Effect of Dietary Macronutrient Composition on AMPK and SIRT1 Expression and Activity in Human Skeletal MuscleB. Draznin1, C. Wang1, 2, R. Adochio1, J. W. Leitner1, M.-A. Cornier1Horm Metab Res 2012; 44(09): 650-655 (https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0032-1312656) Not free - 🙁The researchers recruited 21 lean (11 men, 10 women; avg age 27.8 yrs; avg wt 147.4 lbs), healthy, non-diabetic subjects, all of whom were started on the same five-day eucaloric baseline diet as the subjects in the other study (30% fat, 50% carb, 20% prot). The subjects were then randomized into two different groups, both of which consumed 40% more calories as compared to baseline. These five-day overfeeding diets were either low-carb (50% fat, 30% carb, 20% prot) or low-fat (20% fat, 60% carb, 20% prot). As before, on the fifth day of the overfeeding study, subjects were hospitalized so that insulin clamp studies and muscle biopsies could be done the next morning. Then, unlike with the other study, this same group of subjects came back a month later and went through the process again except in a cross-over fashion so that each subject could act as his/her own control.Low-fat/high-carb overfeeding did not produce any effect of AMPK activity as compared to baseline. But low-carb/high-fat overfeeding produced a significantly increased activation of AMPK.And this activation of AMPK even in the face of overfeeding may explain why it is difficult for most people to gain weight on a true low-carbohydrate diet. Even one with a large dollop of extra calories.Thats the link to the blog post: http://www.proteinpower.com/drmike/inflammation/can-your-food-make-you-fit/
Interesting… I'll have to dig deeper another day and get all my questions answered. Thank you for the post
training log
https://docs.google.com/spreadsheets/d/1yQ7u-n9iU7R910fUgcAEo5NJoUZzT3w1zLC5qYyaGZE/edit#gid=1795865688
This is really interesting, thanks for the share!
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