Hopefully is the key word here. In some transgenic mice models, when leptin levels are really high, but insulin levels are low or baseline, empty fat cells went through apoptosis (literally just falling apart). Whether this happens in humans or not is still only conjecture, but the mice were bred to grow human fat cells, so it is possible and would explain long-term fat loss success stories. It's easier the longer the weight stays off; but we just learned a few years ago that fat cells turnover once every ten years and if they're empty at the time of turnover, they simply die and don't get replaced.So, does Carb Nite kill fat cells? Yes, by emptying them out and helping you to keep them empty. Does it do this in a very short period of time? Maybe....